The Dog Mobility Project

Degenerative Myelopathy (DM) is a devastating neurodegenerative disease that affects the spinal cord of dogs, leading to progressive weakness and paralysis. While there is currently no cure, ongoing research is uncovering promising new insights and potential treatments.

Here are some of the latest breakthroughs in DM research that could offer hope for affected dogs and their owners.

Gene Mutation and Immune System Signaling

Researchers at the University of Florida have identified a crucial link between a gene mutation associated with DM and immune system signaling. Interestingly, this connection was discovered while studying canine hemangiosarcoma, a highly aggressive cancer. This breakthrough suggests that understanding immune system interactions in DM could pave the way for new treatment approaches, not only for dogs but also for humans with similar neurodegenerative conditions.

Intensive Neurorehabilitation and Stem Cell Therapy

A 2023 study has explored the effectiveness of Intensive Neurorehabilitation combined with allogeneic stem cell transplantation (INSCP). The results indicate that this approach is both safe and feasible for dogs with DM. By integrating structured rehabilitation with stem cell therapy, researchers believe they can extend survival time and enhance the quality of life for affected dogs. These findings provide a strong foundation for future clinical applications in both veterinary and human medicine.

Biomarker Test for Diagnosis

A major challenge in diagnosing DM is distinguishing it from other neurological disorders, such as intervertebral disc disease. Researchers at the University of Missouri have found that a biomarker test used to diagnose amyotrophic lateral sclerosis (ALS) in humans can also aid in diagnosing DM in dogs. This test could significantly improve early detection, allowing for timely intervention and better disease management.

Riluzole Clinical Trials

The AKC Canine Health Foundation is funding a clinical study to evaluate riluzole, an FDA-approved drug used for ALS treatment in humans, as a potential therapeutic option for DM. Riluzole is known to help slow neurodegeneration by reducing excitotoxicity in nerve cells. If successful, this trial could lead to the first effective drug treatment for DM, offering hope for extending the lives of affected dogs.

The Role of Physical Rehabilitation

Physical rehabilitation has long been recognized as a crucial component in managing DM. Studies have shown that daily rehabilitation exercises, including hydrotherapy and structured mobility programs, can increase median survival time and delay disease progression. Consistent therapy helps maintain muscle strength and coordination, ultimately improving a dog’s overall well-being despite the progressive nature of DM.

Conclusion

While DM remains a challenging disease, these recent research developments represent significant progress in our understanding and management of the condition. From genetic discoveries and stem cell therapy to biomarker diagnostics and drug trials, scientists and veterinarians are working tirelessly to find better ways to diagnose, treat, and slow the progression of DM. For dog owners, these advancements offer renewed hope for improving the lives of their beloved pets.